The Evolving Science of Pyruvate Kinase Activation

Pyruvate Dehydrogenase

Compare the regulation of the pyruvate dehydrogenase complex in... | Filo

SOLVED: The pyruvate dehydrogenase (PDH) complex catalyzes the oxidativedecarboxylation of pyruvate to acetyl-CoA and CO2. Multiple copiesof pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2),and dihydrolipoyl dehydrogenase (E3) along with five cofactors formthe PDH complex. Biochemists have studied the PDH complex fordecades, in part due to its interesting use of substrate channelingduring catalysis. What is the benefit of substratechanneling? What is the molecular mechanism of subs

SOLVED: (A) A cell is deficient in pyruvate dehydrogenase phosphatase. How would such a deficiency affect cellular metabolism?(B) A cell has a metabolic defect in the citric acid cycle that causes inhibition of pyruvate dehydrogenase kinase 2, and consequent activation of HIF-1, hypoxia-induced factor 1. Compare the metabolic effects of this situation to part (a) of this problem.

SOLVED:If the three enzymes of the pyruvate dehydrogenase complex existed as physically separate proteins rather than as a complex, what effect might this have on the rate of reactions catalyzed by these enzymes?

Describe the five steps in the pyruvate dehydrogenase reaction.... | Filo