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1:30
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Tosyl Group Synthesis
Total Synthesis & Medicinal Chemistry - The Davies Group
emory.edu
Feb 19, 2021
SOLVED: When the reaction of tosyl chloride and an alcohol is performed with triethyl amine instead of pyridine, an unwanted byproduct is often formed in small quantities. Propose a mechanism (show arrow-pushing) that can account for the byproduct formation. Include a BRIEF rationale/explanation for your mechanism (explain the key points and why it makes sense to you). (15 pts)(Tosyl chloride)(Desired product)(Undesired byproduct)(Triethyl amine)
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Consider the reaction between an alcohol and tosyl chloride, followed by nucleophile. Write the condensed formula of the expected main organic product:TsCl pyridineCH3CH2OH2NC
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consider the reaction between an alcohol and tosyl chloride followed by a nucleophile write the condensed formula of the expected main organic product 1 tscl pyridine choh 2 ch chch s chchch 69553
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