APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
vanderbilt.edu
APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Adenomatous polyposis coli (APC) mutations cause Wnt pathway activation in human cancers. Current models for APC action emphasize its role in promoting β-catenin degradation downstream of Wnt receptors. Unexpectedly, we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand. We also ...
Aug 3, 2018
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APC is a tumor suppressor that negatively regulates the Wnt pathway. RKO cells with wild-type (left) and knocked out APC (right). These cells have been stained for beta-catenin (yellow) and DNA (blue) Note the intense staining of beta-catenin upon loss of APC.
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