ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.

Nov 30, 2023 · ZAP-70 deficiency is a rare combined immunodeficiency (CID) with an autosomal recessive pattern of inheritance. The disease was first described in 1989 in a patient of Mennonite descent with CD8 lymphocytopenia [1].

The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement.

ZAP-70 (zeta-associated protein 70) deficiency is an immunodeficiency disorder involving impaired T-cell activation caused by a signaling defect. Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired …

The ZAP70 gene provides instructions for making a protein called zeta-chain-associated protein kinase. This protein is part of a signaling pathway that directs the development of and turns on (activates) immune system cells called T cells. T cells identify foreign substances and defend the body against infection.

ZAP-70 is required for intracellular calcium ion mobilization in response to SDF-1alpha/CXCL12-induced prolonged activation of extracellular signal-related protein kinase in Jurkat T lymphocytes. results suggest a novel functional role for ZAP 70 in nuclear receptor-driven transactivation in T …

Apr 26, 2018 · In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 catalytic activity-dependent and -independent signals in developing and mature T cells.

Oct 1, 2019 · What is ZAP-70 (70-kDa zeta-associated protein), and what can it reveal about a CLL patient’s prognosis? Experts Drs. Nitin Jain, Alessandra Ferrajoli and Javier Munoz explore this prognostic marker and what role—if any—it plays in determining a treatment path.

In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 catalytic activity–dependent and –independent signals in developing and mature T cells.