Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in …
May 18, 2019 · Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal …
Protein kinase C in Wnt signaling: implications in cancer ... - PubMed
Canonical Wnt signaling has been well characterized as one of the most important contributors to tumorigenesis, and it has been implicated in many types of solid tumors. PKC is one of the key …
Detecting PKC phosphorylation as part of the Wnt/calcium …
Here we summarize the current understanding of the Wnt/Calcium pathway and discuss methods of detecting activated/phosphorylated PKC as a result of Wnt signaling in malignant …
Protein kinase C in Wnt signaling: Implications in cancer ... - IUBMB
Sep 9, 2011 · More recent data have pointed out the negative regulation of Wnt signaling by PKC; using a cell-based chemical screen to identify molecules that inhibit Wnt/β-catenin pathway, …
RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent ...
Jan 29, 2010 · Wnt5a/PKCα-dependent phosphorylation on serine residue 35 of RORα is crucial to link RORα to Wnt/β-catenin signaling, which exerts inhibitory function of the expression of …
Protein-kinase-C-mediated beta-catenin phosphorylation …
Nov 15, 2006 · Here we present small-molecule-based identification of protein kinase C (PKC)-mediated beta-catenin phosphorylation as a novel mechanism regulating the Wnt/beta-catenin …
Wnt5a through noncanonical Wnt/JNK or Wnt/PKC signaling ... - PubMed
Mar 21, 2014 · The levels of surfactant protein (SP) C, SPB and SPD, the specific markers of AT II cells, increased in mMSCs when Wnt5a was added to activate noncanonical Wnt signaling, …
Wnt and calcium signaling: β-Catenin-independent pathways
Sep 1, 2005 · Wnt binding leads to the activation of Disheveled (Dsh), which can inhibit the β-catenin destruction complex, that includes APC, Axin, casein kinase 1 (CK-1), and GSK-3. In …
Wnt5a Increases Cardiac Gene Expressions of Cultured Human …
Using both, pharmacological inhibitor as well as genetic ablation in vivo, we identify the novel PKC isoform, PKC delta, to importantly contribute to cardiac gene expression in EPC, indicating …
Crosstalk between Wnt signaling and Phorbol ester-mediated PKC ...
Feb 1, 2016 · In this study, we explored the contribution of PKC isoforms to canonical and noncanonical Wnt signaling pathway in mediating cell migration and an epithelial …
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