Wnt signaling pathway - Wikipedia
Signaling from both the Wnt PCP pathway and canonical Wnt pathway is required for proper convergent extension during gastrulation. Convergent extension is further regulated by the …
The Wnt Signalling Pathway: A Tailored Target in Cancer - PMC
In the non-canonical PCP pathway, Wnt ligands bind to FZD receptors and co-receptor protein tyrosine kinase 7 (PTK7), RAR-related orphan receptor (ROR) or the receptor like tyrosine …
WNT/PCP signaling pathway and human cancer (review)
WNT/planar cell polarity (PCP) signaling pathway controls tissue polarity and cell movement through the activation of RHOA, c-Jun N-terminal kinase (JNK), and nemo-like kinase (NLK) …
Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by ...
Analyses in Drosophila and several vertebrate model organisms have contributed a wealth of information on the regulation of PCP. A key conserved pathway regulating PCP, the so-called …
Wnt/PCP signaling contribution to carcinoma collective cell …
Apr 4, 2019 · Wnt/planar cell polarity (Wnt/PCP) signaling, a branch of non-canonical Wnt signaling, is critical to the establishment and maintenance of polarity in epithelial tissues. …
Wnt signaling in cancer: from biomarkers to targeted therapies …
Apr 2, 2025 · Non-canonical Wnt signaling pathways, such as the Wnt/Ca2 + and Wnt/planar cell polarity (PCP) signaling pathways, also contribute to normal cellular function and cancer. The …
An Overview of Potential Therapeutic Agents Targeting WNT/PCP …
The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell …
From instruction to output: Wnt/PCP signaling in development …
In this review we highlight the latest developments in the PCP field in Drosophila and vertebrates with focus on the organization and stability of core PCP complexes, Wnt input as instructive …
Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer ...
Noncanonical Wingless/Int-1 (Wnt)/planar cell polarity (PCP) signaling is known to control the orientation of the epithelial sheet orthogonal to the apicobasal polarity and convergent …
Wnt/PCP Signaling Contribution to Carcinoma Collective Cell
Apr 15, 2019 · Wnt/PCP signaling components are frequently dysregulated in solid tumors, and aberrant pathway activation contributes to tumor cell migratory properties. Here we summarize …