Nov 11, 2008 · In the present study, we show that Wnt10b driven tumors express low levels of p27 KIP1 (Cdkn1b) and present evidence for post-translational control by a novel Wnt-induced …

Apr 15, 2016 · Repression of p27 and proliferation of GATA4+ve XX somatic cells is promoted through WNT/β-catenin signalling. Unknown signals promote expression of p27 and FOXL2 in …

In this review, we provide an overview of how protein phosphorylation controls WNT/β-catenin signaling, particularly in human cancer. Keywords: β-catenin, CTNNB1, GSK3β, adherens …

Nov 15, 2008 · Loss of the CDK inhibitor p27 (KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors, levels of p27 (KIP1) were extremely low; …

Wnt-induced Cul4A:Ddb1 E3 ubiquitin ligase exclusively targets p27 Kip1 for proteolysis in Wnt-dependent tumors. Cul4A engages an E1 activating enzyme, which transfers ubiquitin transfer …

Apr 15, 2016 · Blocking WNT signalling reduces XX supporting cell proliferation, while stabilising β-catenin signalling promotes proliferation, indicating that the renewal of pre-granulosa cells is …

Since p27 is a major target of Wnt signaling, we speculate that Wnt3a treatment induces cell cycle arrest in stromal cell sheet cultures, which leads more cells entering quiescent stage instead of …

Dec 15, 2008 · We report here that Id-1 inhibits PTEN transcription by downregulating p53 expression, which induces the PI3K/Akt-mediated Wnt signaling pathway and p27 Kip1 …

Aug 5, 2020 · More importantly, Wnt signaling activation significantly reduced senescence in cell sheet cultures by direct regulation of cell cycle inhibitor p27. This study not only characterized …

May 1, 2008 · Loss of the CDK inhibitor p27 KIP1 is widely associated with poor prognosis in human cancer. We found that p27 Kip1 is uniquely degraded in mammary tumors arising from …