In cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the names Wingless and Int-1. [1] .

We define “direct Wnt targets” as genes whose regulatory DNA can be physically associated with T-cell factors (TCFs) or other transcription factors (TFs) and whose expression is modulated by the recruitment of β-catenin to regulatory chromatin by these TFs.

Jan 3, 2022 · Acute liver injury induced by carbon tetrachloride leads to activation of the Wnt/β-catenin signalling pathway, which manifests as an increase in the level of the Wnt target gene AXIN2.

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are ...

Jan 1, 2025 · Wnt signaling is often implicated in stem cell control, as a proliferative and self-renewal signal. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by …

Feb 19, 2024 · In this Review, we summarize the current state of research regarding the evolutionary origin of Wnt signalling, its ancestral function and the characteristics of the primal Wnt ligand, with...

Apr 4, 2025 · Given its pivotal role in cellular communication, aberrant Wnt signaling has been extensively linked to the pathogenesis of various diseases. This review offers an in-depth analysis of the Wnt...

Apr 2, 2025 · Adenomatous polyposis coli (APC) APC is a tumor suppressor gene that regulates β-catenin degradation [65, 66].However, alterations in the APC gene impair Wnt signaling pathways, triggering the abnormal accumulation of β-catenin and facilitating the progression of tumors (Fig. 1).The identification of APC gene mutations serves as a fundamental biomarker, distinguishing cancer patients with ...

Jan 1, 2025 · Wnt signaling is often implicated in stem cell control, as a proliferative and self-renewal signal. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by …

Mar 1, 2001 · The Wnt genes encode a large family of secreted protein growth factors that have been identified in animals from hydra to humans. In humans, 19 WNT proteins have been identified that share 27% to 83% amino-acid sequence identity and a conserved pattern of 23 or 24 cysteine residues.