Therapeutic blood-brain barrier modulation and stroke ... - Nature
Jun 2, 2023 · Our findings reveal systemic efficacy of a bioengineered FZD 4 -selective WNT surrogate during ischemic BBB dysfunction, with potential applicability to adult CNS disorders …
Modulation of Wnt/β-catenin signaling promotes blood-brain …
Wnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions. In the present study, a …
Engineered Wnt ligands enable blood-brain barrier repair in
Feb 18, 2022 · However, safe therapeutic use of Wnt ligands is complicated by their pleiotropic Frizzled signaling activities. Taking advantage of the Wnt7a/b-specific Gpr124/Reck co …
Redesigning Wnt for blood–brain barrier repair - Nature
Mar 10, 2022 · Now, a study in Science reports the development of Wnt analogues that can repair the BBB in animal models of various neurological disorders. The BBB comprises a dynamic …
Activation of Wnt/β-catenin pathway mitigates blood-brain barrier ...
Dec 19, 2022 · In the cerebral microvessels of APP/PS1 mice and amyloid-β-treated brain endothelial cells, we found suppressed Wnt/β-catenin signalling triggered by an increase of …
Engineered Wnt ligands enable blood-brain barrier repair in ...
Feb 18, 2022 · In a "hit-and-run" adeno-associated virus-assisted CNS gene delivery setting, these new Gpr124/Reck-specific agonists protected BBB function, thereby mitigating …
Wnt signaling mediates acquisition of blood–brain barrier properties …
Nov 10, 2021 · Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β …
Wnt/β-catenin signaling is required for CNS, but not non-CNS ...
Our data demonstrates that Wnt/β-catenin signaling is essential for CNS angiogenesis and the expression of BBB-specific transport molecules. This provides evidence that angiogenesis and …
Activation of Wnt/β-catenin pathway mitigates blood–brain …
Jul 5, 2022 · Targeting LRP6 in the Wnt/β-catenin pathway in BECs alleviates BBB dysfunction. In the Alzheimer’s disease (AD) brain, Aβ oligomers suppress Wnt/β-catenin signalling in the …
Modulation of Wnt/β-catenin signaling promotes blood-brain barrier ...
Dec 23, 2019 · Wnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions.