Mar 3, 2020 · Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation.

Mar 2, 2022 · Osteosarcoma cell lines expressing WT1 under an inducible tetracycline-regulated promoter mediate apoptosis through reduced synthesis of the EGFR . Also, WT1 can negatively regulate growth factor receptors such as EGFR and the insulin receptor, repressing survival signals and promoting death .

WT1-mediated apoptosis was associated with reduced synthesis of the epidermal growth factor receptor (EGFR), but not of other postulated WT1-target genes, and it was abrogated by constitutive expression of EGFR.

Among PDSTFs in urinary exosomes, Wilms tumor 1 (WT1) levels reflected damage of diabetic glomeruli in the patients. Urinary exosomal WT1 can predict the decline in eGFR for the following several years.

Mar 27, 2013 · We found that the level of exosomal WT1 were associated with a significant increase in urine protein-to-creatinine ratio, albumin-to-creatinine ratio, and serum creatinine as well as a decline in eGFR.

Jul 17, 2014 · Here we demonstrate that lack of Wt1 abolishes fibroblast growth factor (FGF) and induces BMP/pSMAD signalling within the metanephric mesenchyme. Addition of recombinant FGFs or inhibition of...

Nov 1, 2020 · Syndromic phenotype, types of WT1 mutations, age onset, initially estimate glomerular filtration rate (eGFR), sequence timing and immunosuppression treatment were treated as categoric variables. All patients were stratified by renal function decline status or by sequence timing.

Jul 10, 2021 · In this instance, WT1 mRNA gene expression in urinary exosome of DN patients showed significant correlation with the reduction of estimated glomerular filtration rate (eGFR) representing renal function.

Feb 27, 2015 · Wt1 is expressed in cap mesenchyme (CM) surrounding the ureteric bud (UB) and at very low level in stromal mesenchyme (SM). Wt1 expression is increased in pre-tubular aggregates (PTAs) that begin to undergo mesenchymal to epithelial transition to form the …

Mar 15, 2007 · The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival.