Mar 30, 2025 · WT1 is a tumor suppressor gene associated with the development of Wilms' Tumor, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently identified in acute myeloid leukemia and associated with …

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p. [5][6][7][8] This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine -rich …

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein activity is limited to a structure known as the glomerulus, which filters blood through the …

Apr 30, 2020 · WT1 disorder is characterized by congenital /infantile or childhood onset of steroid-resistant nephrotic syndrome (SRNS), a progressive glomerulopathy that does not respond to standard steroid therapy.

There is a specific gene known as WT1, located on chromosome 11 at position p13, which is altered in patients with the WT1-related WT syndromes. The WT1 gene produces a protein known as a “transcription factor."

In the present study, we describe a set of leukemia and lymphoma cell lines, which are carefully characterized for WT1’s unique properties and thoroughly screened for sequence alterations in WT1 and other genes important for leukemogenesis.

Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for …

Mar 15, 2007 · The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival.

Dec 1, 2023 · Wilms' tumor suppressor (WT1) gene is a transcription factor and an RNA-binding protein involved in the differentiation and survival of the cells of several organs, including the kidney and urinary tract, gonads, heart, and nervous system.

Feb 8, 2025 · This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor.