A variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. [1]

Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret. VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known.

Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation.

Sep 29, 2021 · To get a handle on a variant’s role in cancer, researchers must test millions of people, and share their data. If a VUS is found in a significant number of people who have cancer, but absent in those who don’t, there’s an increased likelihood that it could be associated with higher cancer risks.

Rg: Rg is defined as the mass-weighted root mean square distance of collected atoms from their common center of mass. We utilized the Rg to test the compactness of the native and variant protein structure.

Feb 3, 2020 · Variants of uncertain significance (VUS) were present in 108 (28%) of 385 individuals who had echocardiographic data. Serial evaluation for periods up to 14 years revealed that VUS carriers had relatively greater increments in left ventricular end‐diastolic and end‐systolic diameters over time when compared with noncarriers.

Variants with insufficient or conflicting evidence supporting disease association, such that they cannot be classified as ‘pathogenic/likely pathogenic’, nor as ‘benign/likely benign’, are VUSs. The presence of a VUS, even in a relevant gene or chromosome, does not …

A variant of uncertain significance (VUS) describes a genomic variant about which there is insufficient data to conclude that it is either benign or pathogenic.

3 days ago · When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS).

Multi-gene panels for cardiogenetic conditions are cost-effective and informative when pathogenic variants are identified, but can become a source of frustration and potential misunderstanding when the result is a variant of uncertain significance (VUS).