Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple domains characteristic of signal transducing proteins, including a Dbl homology domain, a hallmark of a guanine nucleot …

Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the thymus. Furthermore, Vav1-deficient thymocytes show greatly reduced TCR-induced intracellular calcium flux.

In mature T cells, Vav1 deficiency reduces TCR-induced proliferation, intracellular Ca 2+ flux, upregulation of activation markers, and cytokine secretion (18, 20–25). Vav1 is also required to transduce TCR signals that lead to actin polymerization and TCR clustering (21, 25).

Engagement of CD226 induced the tyrosine phosphorylation of VAV1 and synergized with T cell receptor (TCR) signals to specifically enhance the production of interleukin-17 (IL-17) by primary human CD4 + T cells.

Vav1 is an important mediator of T cell receptor (TCR) signaling and is required for the development of T cells in the thymus and for their activation and proliferation in response to antigen stimulation.

The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to microclusters and to the IS in primary CD4 + and CD8 + T cells.

Nov 15, 2012 · The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to microclusters and to the IS in primary CD4(+) and CD8(+) T cells.

Vav1 is a proto-oncogene that plays crucial roles in the signaling pathways initiated by the T cell receptor (TCR) (1). Vav1 regulates T cell proliferation and effector function through its impacts on GTPases, calcium responses, mitogen-activated protein kinases, and the cytoskeleton (2 – 5).

Jul 2, 2015 · Vav1, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T-cell receptor (TCR) signaling cascade is tyrosine phosphorylated rapidly in response to T-cell activation.

Oct 15, 2006 · In this study, we report three novel findings regarding the regulation of FOXO1 in T cells: 1) the activity of FOXO1 is tightly regulated upon TCR/CD28 engagement; 2) Vav1 is an important component in TCR/CD28 signaling pathways leading to phosphorylation and inactivation of FOXO1, resulting in down-regulation of the cell cycle inhibitor p27 ...