VMAT2 is an integral membrane protein that transports monoamines —particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine —from cellular cytosol into synaptic vesicles. [6] .

VMAT2 inhibitors (vesicular monoamine transporter-2 inhibitors) are used to treat movement disorders such as Huntington’s disease or tardive dyskinesia.

Nov 1, 2023 · Here we describe cryo-electron microscopy structures of human VMAT2 complexed with serotonin and three clinical drugs at 3.5–2.8 Å, demonstrating the structural basis for transport and inhibition.

Apr 2, 2019 · The vesicular monoamine transporter type 2 (VMAT2) inhibitors are agents that cause a depletion of neuroactive peptides such as dopamine in nerve terminals and are used to treat chorea due to neurodegenerative diseases (such as Huntington chorea) or dyskinesias due to neuroleptic medications (tardive dyskinesia).

Nov 1, 2023 · Here we report cryo-electron microscopy structures of the human vesicular monoamine transporter VMAT2 in complex with the antichorea drug tetrabenazine, the antihypertensive drug reserpine or the...

Jan 2, 2024 · Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage and subsequent release in neurons. Impaired...

VMAT2 is the CNS vesicular transporter for not only the biogenic amines DA, NE, EPI, 5-HT, and HIS, but likely also for the trace amines TYR, PEA, and thyronamine (THYR).

VMAT1 and VMAT2 are acidic glycoproteins with a molecular weight of approximately 70 kDa. [4][10] Both isoforms are transmembrane proteins with 12 transmembrane domains (TMDs). [4] VMATs function by loading monoamines—dopamine, serotonin, histamine, norepinephrine, and epinephrine—into transport vesicles. [11] .

Vesicular Monoamine Transporter 2 (VMAT 2) is an integral membrane protein that removes serotonin and other monoamine neurotransmitters from the cytoplasm, packaging them into secretory vesicles for transport and release at the presynaptic terminal. You might find these chapters and articles relevant to this topic.

In the monoamine system, this process is carried out by the vesicular monoamine transporters (VMAT1 and VMAT2). These proteins are responsible for vesicular packaging of dopamine, norepinephrine, serotonin, and histamine.