Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34. [5]

The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and ...

VEGF-C C156S is an engineered vascular endothelial growth factor C (VEGF-C) variant that interacts predominantly with VEGF receptor 3 (VEGFR-3) (Joukov et al., 1998). VEGFs that interact with all three receptors do not naturally exist, …

Nov 26, 1999 · Abstract —Vascular endothelial growth factor (VEGF) is a key modulator of angiogenesis during development and in adult tissues, whereas the related VEGF-C has been shown to induce both lymphangiogenesis and angiogenesis.

Data indicate that microRNA miR-101 negatively regulates vascular endothelial growth factor C (VEGF-C) protein expression post-transcriptionally. VEGF-C plays a crucial role in tumor lymphangiogenesis and lymph node metastasis of ovarian cancer.

The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed by a range of human tumor cells in addition to lymphatic endothelial cells.

Nov 19, 2020 · Instead, VEGF-C delivery significantly increased intimal SMCs (Figure [C]), and analysis of lipid accumulation in intimal cells showed a significant decrease in the loading of SMCs (Figure [C]) but not of macrophages (not shown) in F8-VEGF-C–treated mice.

Mar 30, 2025 · VEGFC (Vascular Endothelial Growth Factor C) is a Protein Coding gene. Diseases associated with VEGFC include Lymphatic Malformation 4 and Hereditary Lymphedema Id. Among its related pathways are Apoptotic Pathways …

Vascular endothelial growth factor (VEGF) has potent angiogenic and mitogenic actions. It induces nitric oxide synthase in endothelial cells, and is likely to play a part in decreasing vascular tone and blood pressure in healthy pregnancy.

Recently, vascular endothelial growth factor-C (VEGF-C or VEGF-2) was described as a specific ligand for the endothelial receptor tyrosine kinases VEGFR-2 and VEGFR-3.