The VA1.3 is a non-toxigenic V. cholerae O1 El Tor Inaba strain with an insertion of the ctxB gene (under the control of the ctx promoter) into the hlyA gene. This strain naturally lacked the CTXΦ prophage and has proven to be non-reactogenic in a rabbit ileal loop assay.

Jan 21, 2021 · Vibrio cholerae is a global health threat and a model enteric pathogen that causes the human disease cholera. Here, we report the complete genome sequence of the seventh-pandemic V. cholerae O1 El Tor strain C6706.

Vibrio cholerae serogroup O1, the causative agent of the diarrheal disease cholera, is divided into two biotypes: classical and El Tor. Both biotypes produce the major virulence factors toxin-coregulated pilus (TCP) and cholera toxin (CT).

In general, strains outside of these serogroups (commonly referred to as "non-O1/non-O139 V. cholerae ") are non-pathogenic or asymptomatic colonizers in humans, or cause mild, sporadic illness (such a gastroenteritis, wound or ear infections) in otherwise healthy hosts.

Our study suggests that Queensland waterways can harbor highly divergent V. cholerae strains and serve as a reservoir for various V. cholerae-associated virulence genes which could be shared among O1 and NOVC V. cholerae strains via …

Vibrio cholerae O1 is the organism responsible for historic pandemics of cholera since 1816, including the current pandemics. Contamination may be hand transmitted through water drinking (and flies).

Here, we report a comprehensive genome analysis of the whole set of V. cholerae O-serogroup reference strains to provide an overview of this important bacterial pathogen.

May 14, 2022 · Somatic antigen agglutinable type-1/139 Vibrio cholerae (SAAT-1/139-Vc) members or O1/O139 V. cholerae have been described by various investigators as pathogenic due to their increasing virulence potential and production of choleragen.

V cholerae serogroup O139, which arose in October of 1992 in India and Bangladesh, may become the cause of the 8th great pandemic of cholera. Other vibrios may also be clinically significant in humans, and some are known to cause diseases in domestic animals.

Feb 8, 2024 · Vibrio cholerae O1 causes the diarrheal disease cholera, and the small intestine is the site of active infection. During cholera, cholera toxin is secreted from V. cholerae and induces a massive fluid influx into the small intestine, which causes vomiting and diarrhea.