Key points: • In a retrospective cohort of 57 metastatic melanoma patients treated with BRAF/MEK inhibitors, a TMTV > 56 cm 3 at baseline [18 F]FDG PET/CT was significantly correlated with a shorter PFS and OS.

Disease burden is a critical determinant of outcomes in CAR‐T therapy for B‐cell lymphomas, and one of the most widely used techniques for its assessment is Total Metabolic Tumor Volume (TMTV) measured via [18 F]FDG PET/CT. Biological …

Nov 15, 2021 · We aimed to investigate if baseline total metabolic tumour volume (TMTV) and therapy-response assessment by [18 F]FDG PET/CT have a prognostic role on progression-free survival (PFS) and overall survival (OS) in patients with metastatic melanoma receiving BRAF ± …

Using the optimal threshold by ROC curve to classify patients into three TMTV1 subgroups (0 cm3; 0–57 cm3; >57 cm3), TMTV1 prognostic stratification was independent of PERCIST criteria on both PFS and OS, and significantly outperformed them.

High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Abstract. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to …

Dec 1, 2021 · Baseline TMTV appears to be a useful independent prognostic factor for predicting relapse in advanced-stage HL in ABVD subgroup, with a tendency of survival curves separation in BEACOPP subgroup.

Baseline TMTV is a strong prognostic factor of POD24 and PFS in advanced FL, even in the era of antibody maintenance. SUV max was not predictive of PFS in either treatment arm. TMTV combined with FLIPI score identified a subgroup of patients (16%) at high risk of relapse with a 6-year PFS of 41.0%.

Dec 2, 2020 · Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18 F-fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) in T-LBL. Thirty-seven treatment naïve T-LBL patients with PET-CT scans were enrolled.

Apr 4, 2018 · High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose–positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value.

Aug 12, 2022 · The determination of total metabolic tumor volume (TMTV) is generally based on semi-automatically defined volumes of interest (VOI) around the tumor using a software visualization program; however, often these VOIs are manually adjusted by the nuclear medicine specialist to include the entire tumor and avoid healthy tissues.