Jun 28, 2013 · The overexpression of TRAF2 augmented the cytoplasmic expression of TRAF4 which promoted cell proliferation and inhibited cell apoptosis by activating NF-κB nuclear transcription. TRAF4 may play an important role in the activation of NF-κB via TRAF2.

Jun 13, 2013 · Phosphorylation of TRAF2 (at Ser11 and Ser55 by PKCζ or IKKϵ, and at Thr117 by PKCδ and PKCϵ), which promotes K63-linked ubiquitination of TRAF2 and NF-κB activation, has been demonstrated in TNFα signaling or in transformed cells [235–238].

The structures of the TRAF domain of TRAF2, TRAF3, and TRAF6 and their receptor complexes were elucidated around year 2000 (24–26), and those of TRAF1, TRAF4, and TRAF5 and their receptor complexes were examined recently (27–32). In this review, we discuss the current understanding of the structural and molecular diversity of the TRAF ...

TRAF4. Unique among the TRAF family, TRAF4 is mainly involved in developmental, morphogenic, and oncogenic processes [148–153]. However, TRAF4 also regulates inflammation and inflammatory responses mediated by GITR, TLRs, NOD2, IL-17R, and IL-25R [3,153–161].

Gain-of-function alterations (gene amplification and overexpression) are common for TRAF1, TRAF4, TRAF5, and TRAF6 in human cancers, and are also identified for TRAF2 in epithelial cancers.

TNF-associated factor 2 (TRAF2), a 56kD protein, was discovered through yeast two hybrid screening for proteins interacting with the c-terminal region of human TNF receptor 2. 1 Along with TRAF1, TRAF2 was one of the first members of the TRAF protein family to be identified.

Jun 28, 2013 · In this study, we examined the regulation function of TRAF2 to the cytoplasmic/nuclear distribution of TRAF4 in the breast cancer cell line. Using cell immunofluorescent staining, we found that TRAF2 and TRAF4 …

TRAF2 regulates the biology of breast cancer cells via the Akt signaling pathway. In MCF-7 and BT-549 cell lines, regulation of TRAF2 expression significantly affected the extent of Akt ubiquitination but did not affect the total Akt level. In addition, Akt phosphorylation changed with TRAF2 levels. Reports show that TRAF4 binds to Akt.

Jan 2, 2019 · TRAF2, a RING finger adaptor protein, plays an important function in tumor necrosis factor (TNF)- and TNF-like weak inducer of apoptosis (TWEAK)-dependent signaling, in particular during inflammatory and immune responses.

Dec 25, 2024 · TRAF4 (TNF Receptor Associated Factor 4) is a Protein Coding gene. Diseases associated with TRAF4 include Lung Cancer and Intraneural Perineurioma. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and NGF Pathway.