Targeting the Wnt pathways for therapies | Molecular and …
Sep 11, 2014 · Another class of compounds inhibits tankyrases (TNK1 and 2) – enzymes among other functions found to destabilize Axin. TNK inhibition results in prevention of β-catenin …
Whole proteome analysis of human tankyrase knockout cells reveals ...
Dec 20, 2017 · Quantitative analysis of the proteome of tankyrase double knockout cells using isobaric tandem mass tags reveals targets of degradation, including antagonists of the Wnt/β …
Tankyrase inhibitors: emerging and promising therapeutics for …
Nov 17, 2020 · Tankyrase, a member of poly (ADP-ribose)polymerase family, mediates Wnt signal transduction and has emerged as a new molecular target for the therapy of different …
WNT signaling in glioblastoma and therapeutic opportunities
Dec 7, 2015 · In this review, we will summarize the experimental evidence supporting oncogenic roles of WNT signaling in GBM and discuss current progress in the targeting of WNT signaling …
Wnt Signaling in the Regulation of Immune Cell and Cancer …
Wnt ligands (Wnt3a, Wnt5a, Wnt5b, and Wnt16) and receptors (FZD1 and FZD5) take part in the regulation of immune cells. The major role of Wnt signaling in B cells, T cells, and NK cells is …
Combination therapies with Wnt signaling inhibition: A better …
Nov 1, 2024 · Tankyrase (TNK) 1 and TNK2 are two isoforms of poly-ADP-ribosylating enzymes that stimulate the ubiquitylation and proteasomal degradation of Axin, an essential component …
Wnt signaling: Modulating tumor-associated macrophages and …
May 1, 2024 · Recent studies have revealed that Wnt signaling pathways critically control the interplay between cancer cells and tumor-associated macrophages (TAMs) in the tumor …
Tankyrase Inhibitor - an overview | ScienceDirect Topics
Tankyrase inhibitors (TNKSi) are small molecules that induce Axis inhibition protein 1/2 stabilization, abrogating Wnt/β-catenin signaling.4 Several TNKSi, including XAV939, 138 IWR …
Emerging Role and Therapeutic Implication of Wnt Signaling …
Noncanonical Wnt ligand (such as the Wnt5a, a typical noncanonical Wnt) binds to its receptor (Fzd) and coreceptor (Ror1/2) and triggers the noncanonical signaling cascades, which …
Inhibition of Wnt/Beta-Catenin Pathway Impairs Natural Killer (NK ...
Nov 5, 2020 · The discovery of pathways that regulate AML cell apoptosis in response to NK cells activation may represent a potential therapeutic target. It is known that the Wnt/beta-catenin …