Jul 20, 2008 · Thus, TRADD is an essential component of TNFR1 signaling and has a critical but apparently cell type–specific function in TRIF-dependent TLR responses. Tumor necrosis factor (TNF; A002291)...

TNFR1, being the main receptor transducing the signals from TNFα, is one of the best-studied receptors in the TNFR superfamily. TNFα was initially characterized as a cytokine that can cause the necrosis of tumors.

Jan 24, 2014 · TNFR-1-associated death domain (TRADD) protein is an adapter molecule that bridges the interaction between TNFR-1 and receptor-interacting serine/threonine-protein kinase 1 (RIP1). However, the molecular mechanism of the complex formation of …

By probing the interaction between the receptor and its downstream signaling molecule (TRADD) our findings support a new model of TNFR1 activation in which varying conformational states of the receptor act as a molecular switch in determining receptor function.

Feb 11, 2019 · Based on these characteristics, we propose a model in which the death receptor-specific activities of TRADD, RIPK1, and FADD are traced back to their hierarchically different position in TNFR1-...

By generating TRADD-deficient mice, we demonstrated that TRADD plays a significant role in tumor necrosis factor receptor-1 (TNFR1) signaling by orchestrating the formation of TNFR1 signaling complexes.

Tumor necrosis factor receptor 1 (TNFR1) and Toll-like receptors (TLRs) regulate immune and inflammatory responses. Here we show that the TNFR1-associated death domain protein (TRADD) is critical in TNFR1, TLR3 and TLR4 signaling.

May 19, 1995 · We have identified a novel 34 kDa protein, designated TRADD, that specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating programmed cell death. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa B.

May 1, 2011 · TNFR-associated death domain protein (TRADD) is a key effector protein of TNFR1 signaling. However, the role of TRADD in other death receptor (DR) signaling pathways, including DR3, has not been completely characterized.

TRADD is an adaptor protein. The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A / TNFR1 and mediates programmed cell death signaling and NF-κB activation.