One of the main therapies involves Tumor Necrosis Factor alpha (TNF-α) inhibitors. In the RA immune-environment, TNF-α has been shown to have an influential and extensive but as yet poorly understood effect on T reg function in vivo, and undoubtably an important role in the treatment of RA.

Immunotherapy has markedly improved treatment outcomes in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α antagonists, such as infliximab (IFX), etanercept (ETN), adalimumab (ADA), golimumab (GOLI) and certolizumab pegol (CZP) have been widely used for the treatment of …

The role of TNF-α in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). TNF-α is mainly secreted by macrophage and Th1 cells. In RA, TNF-α activates synovial fibroblasts, which causes the overproduction of cathepsins and MMP.

Oct 12, 2023 · In summary, 25 years of clinical experience with biologic TNF inhibitors in the management of RA have established a highly favourable benefit versus risk profile and remarkable overall safety...

Nov 14, 2023 · TNF(tumor necrosis factor): Tumor necrosis factor is a substance in your body that causes inflammation. Learn about the role it plays in diseases like rheumatoid arthritis (RA).

Sep 15, 2016 · One of the main therapies involves Tumor Necrosis Factor alpha (TNF-α) inhibitors. In the RA immune-environment, TNF-α has been shown to have an influential and extensive but as yet poorly understood effect on T reg function in vivo, and undoubtably an important role in the treatment of RA.

Jul 3, 2023 · Tumor necrosis factor (TNF) plays a central role in the pathogenesis of several inflammatory conditions, including rheumatoid arthritis (RA). TNF is made intracellularly, mainly by activated macrophages. The precursor TNF is converted to soluble TNF after proteolysis by the TNF-converting enzyme.

Sep 1, 2005 · Tumour necrosis factor-alpha (TNFα) is central to pathogenesis of many inflammatory diseases including rheumatoid arthritis (RA). In patients with RA, TNFα is produced mainly by macrophages and has pleiotropic effects including upregulation of proinflammatory molecules, induction of cellular proliferation and increased vascular permeability.

Owing to the important role of TNF-α in RA, the TNF-α-producing cells and the dynamics of its expression, the direct and indirect action of this cytokine and possible biological therapy for RA are described.

Dec 6, 2022 · What Is a TNF Inhibitor? TNF inhibitors are drugs that help stop inflammation. They're used to treat diseases like rheumatoid arthritis (RA), juvenile arthritis, psoriatic arthritis, plaque...