May 23, 2022 · TFE3 fusions are most closely associated with Xp11 translocation renal cell carcinoma, alveolar soft part sarcoma, melanotic Xp11 renal cell carcinoma, some PEComas and others. Although increased TFE3 expression is seen in some solid pseudopapillary pancreatic neoplasms, these have been negative for the gene fusion.

Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene. [5][6][7] TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991). [supplied by OMIM] [7]

Mar 30, 2025 · TFE3 (Transcription Factor Binding To IGHM Enhancer 3) is a Protein Coding gene. Diseases associated with TFE3 include Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies and …

Dec 17, 2024 · TFE3 rearranged renal cell carcinoma (TFE3 rRCC) is the most common subtype of renal cell carcinoma within the MiT translocation family.

The TFE3 gene is encoded by 14,749 base pairs (bp) on chromosome Xp11.22 and produces a 3,431-bp mRNA transcript consisting of a 238-bp 5′ untranslated region (UTR) followed by ten coding exons and a 1,427-bp 3′ UTR (NM_006521.4). The coding region includes a start codon in exon 1 and stop codon in exon 10.

Mar 11, 2023 · TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and...

Feb 6, 2025 · Here we report that TFE3 fusions transcriptionally rewire tRCCs toward oxidative phosphorylation (OXPHOS), contrasting with the highly glycolytic nature of most other renal cancers.

Oct 26, 2021 · TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991). Macchi et al. (1995) cloned the TFE3 gene.

TFE3’s ability to increase number of lysosomes is TFEB-independent, since its effect is observed in TFEB-depleted cells (Martina et al 2014). Importantly, TFEB and TFE3 induce expression of a small subset of autophagy genes.

Transcription factor binding to IGHM enhancer 3 (TFE3) is a gene that encodes a protein that promotes the expression of genes downstream of transforming growth factor beta signaling.