Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell …
IL2-inducible T-cell kinase (ITK), a member of the Tec family tyrosine kinases, is the predominant Tec kinase in T cells and natural killer (NK) cells mediating T cell receptor (TCR) and Fc …
Itk Promotes the Integration of TCR and CD28 Costimulation
May 15, 2021 · SLP-76 binds the Tec-family tyrosine kinase, Itk, which phosphorylates SLP-76 Y173 and PLC-γ1 Y783. In this study, we identified TCR-inducible, Itk-mediated …
Differential roles of ITK-mediated TCR signals in tissue-specific ...
ITK is a Tec family non-receptor tyrosine kinase that plays multiple roles downstream of the TCR signaling. During the TCR signaling, ITK forms a complex with the adaptor molecule Slp-76, …
Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in ...
ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well …
ITK degradation to block T cell receptor signaling and overcome ...
Interleukin (IL)-2-inducible T cell kinase (ITK), a TEC-family kinase, is essential for T cell receptor (TCR) signaling. ITK functions as a tuning dial to translate variations in TCR signal strength …
ITK signalling via the Ras/IRF4 pathway regulates the ... - Nature
Jun 21, 2017 · Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system …
TCR/ITK Signaling in Type 1 Regulatory T cells - PubMed
ITK signaling downstream of the T-cell receptor (TCR) is critical for T-cell subset differentiation and function. Upon activation by TCR, ITK is critical for Ras activation, leading to downstream …
TEC-family kinases: regulators of T-helper-cell differentiation
Apr 1, 2005 · TEC-family kinases have a central role in the propagation of the signal induced by engagement of the T-cell receptor (TCR). ITK (interleukin-2-inducible T-cell kinase) forms a …
Targeting ITK signaling for T cell-mediated diseases - PMC
IL-2-inducible T cell kinase (ITK) is essential for proximal T cell receptor (TCR) signaling. Following TCR ligation, ITK is recruited to the cell membrane where it interacts with Linker for …
The kinase ITK controls a Ca2+-mediated switch that balances
Jul 23, 2024 · These findings suggest potential strategies for fine-tuning TCR signal strength through ITK to control the balance of T H 17 and T reg cells. Immune function mediated by T …