Mar 30, 2025 · SYT4 (Synaptotagmin 4) is a Protein Coding gene. Diseases associated with SYT4 include Pontocerebellar Hypoplasia, Type 2E and Pheochromocytoma. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene. [5] [6]

Jan 11, 2009 · Syt IV is an activity-induced brain protein with no known Ca 2+ -dependent interactions and its subcellular localization and biological functions have sparked considerable controversy. We...

Feb 10, 2011 · Synaptotagmin-4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of synaptotagmin-4 and thus enhanced negative regulation of oxytocin release. Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obesogenic.

May 17, 2009 · Synaptotagmin-IV (syt-IV) is a membrane trafficking protein that influences learning and memory, but its localization and role in synaptic function remain unclear. We found that syt-IV...

Feb 1, 2024 · In the present study, we discovered that synaptotagmin-4 (Syt4), an immediate-early gene 22 that modulates the interaction of neurotransmitter release, synaptic transmission, and Ca 2+ entry...

Synaptotagmin-4 (SYT4) is a membrane protein that regulates membrane traffic in neurons in a calcium-dependent or calcium-independent manner. In melanocytes, the intracellular free calcium ion (Ca²⁺ ) may be important for dendrite growth and melanogenesis.

Synaptotagmin-4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of syn-aptotagmin-4 and thus enhanced negative regulation of oxytocin release. Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obeso-genic.

Feb 10, 2011 · Evidence is provided to support a critical role for Syt4 in negative regulation of oxytocin release, which in turn is responsible for diet-induced obesity, raising the possibility of using Syt4 as a new antiobesity target.

Feb 8, 2025 · Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca(2+) influx via TRPM1 channels. Syt4 Overexpression Represses Basal Insulin Secretion and Impairs Islet Morphogenesis.