Spleen Tyrosine Kinase (Syk) is widely expressed in the immune system and functions in the transmission of inflammatory signals via ITAM-bearing cell surface receptors. The broad expression pattern and importance of Syk in regulating innate immunity and the inflammatory response have led to signific …

May 15, 2023 · Spleen tyrosine kinase (SYK) is a cytoplasmic kinase that couples immune cell receptors to induce intracellular signaling pathways and plays a central role in adaptive and inflammatory immune...

May 14, 2010 · Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse...

Jan 1, 2025 · Spleen tyrosine kinase (SYK) exhibits diverse biological activities and participates in complex signaling pathways. SYK has vital roles in cancer, autoimmune diseases and other disorders. An overview of the development of SYK inhibitors hints at routes for future drug discovery efforts.

Jun 8, 2023 · Here we report that Spleen Tyrosine Kinase (Syk) is a key mediator of EC barrier disruption and lung vascular leak in sepsis. Inhibition of Syk by pharmacological or genetic approaches, each reduced thrombin-induced EC permeability. Mechanistically, Syk associates with and phosphorylates VE-cadherin to cause EC permeability.

Oct 1, 2021 · In this study, we show that Vav1 and Syk interact in lung carcinoma cell lines similarly to hematopoietic cells. Moreover, Syk, like Vav1, interacts with β-catenin and both proteins modulate its post-translational modifications.

Hypermethylation leads to silencing of the Syk gene in human lung carcinoma. Methylation of the Syk promoter and loss of Syk expression in lung cancer are independent biomarkers, a determination which may offer guidance for selecting appropriate diagnoses and treatments.

In cancers of non-immune cells, SYK provides a pro-survival signal, but can also suppress tumorigenesis by restricting epithelial-mesenchymal transition, enhancing cell-cell interactions and inhibiting migration.

Herein, we found that SYK regulates the plasticity of cells in an epithelial state and is associated with their sensitivity to c-Metis both in vitro and in vivo in PDX models with c-Met overexpression regardless of MET gene status.

May 15, 2023 · Herein, we found that SYK regulates the plasticity of cells in an epithelial state and is associated with their sensitivity to c-Metis both in vitro and in vivo in PDX models with c-Met overexpression regardless of MET gene status.