It is present in both the embryonic and adult brain. In embryonic life, the SVZ refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. [3] .

Oct 10, 2023 · Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ) and induces ectopic migration of newborn cells towards the site of injury. Here, we characterize the...

Nov 23, 2020 · In the mouse brain, two distinct pools of NSC, found in the subventricular zone (SVZ) of the lateral ventricle walls and in the dentate gyrus of the hippocampus, produce new neurons that functionally integrate into preexisting circuits during lifetime (4–6).

Jul 14, 2021 · Here, we present a single-cell RNA-sequencing dataset of the adult mouse V-SVZ revealing two populations of NSPCs that reside in largely non-overlapping domains in either the dorsal or ventral V-SVZ.

In this review, we will discuss potential components of the SVZ stem cell niche, i.e., extracellular matrix composition and brain vasculature, and their possible key role in establishing and maintaining this niche during fetal neocortical development.

Jan 5, 2023 · Here we employ single-nucleus RNA-sequencing (snRNA-seq) of the SVZ from mice subjected to a bTBI. This data-set, including 15272 cells (7778 bTBI and 7494 control) representing all SVZ cell...

Nov 27, 2018 · We used comprehensive and untargeted single-cell RNA profiling to generate a molecular cell atlas of the largest germinal region of the adult mouse brain, the subventricular zone (SVZ).

Dec 8, 2020 · Adult neural stem cells (NSC) serve as a reservoir for brain plasticity and origin for certain gliomas. Lineage tracing and genomic approaches have portrayed complex underlying heterogeneity within the major anatomical location for NSC, the subventricular zone (SVZ).

Mar 4, 2025 · Images from SVZ-mutated mice show that tdTomato-positive cells were initially localized in the rostral SVZ, where mutations were introduced. Over time, these cells migrate to the RC and proliferate to form a tumor; however, there is no tumor formation in the control group. The white dashed line indicates the SVZ and RC sites.

2 days ago · Exogenous administration or gene delivery of Wnt-3a after cerebral ischemia in mice enhances the proliferation of NSCs in the SVZ, and promotes migration of neuroblasts toward the ischemic cortex and neuronal differentiation, thus promoting functional recovery [49, 50]. Our study showed that NBP activated the Wnt/β-catenin pathway, promoted ...