A positive result for SSA (Ro) or SSB (La) antibodies is highly suggestive of a diagnosis of Sjogren syndrome. The presence of isolated anti-SS-B/La antibody has low positive predictive value of Sjogren syndrome.

Feb 11, 2019 · When anti-SSA levels are elevated in SLE, it is often in antinuclear antibody (ANA) – negative lupus. Sjögren’s antibodies (SS-B) is detected in approximately 15% of patients with Sjögren’s Syndrome. Sjögren’s antibody (SS-B) is present …

Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive, especially those with signs and symptoms consistent with Sjogren syndrome or lupus erythematosus. This test is not useful in patients without demonstrable antinuclear antibodies.

The anti-Ro/SSA and anti-La/SSB antibody systems and the clinical significance of these antibodies are reviewed here. An overview of the ANAs important in SLE and in related autoimmune diseases and the clinical significance of autoantibodies directed against double-stranded deoxyribonucleic acid (dsDNA), U1 ribonucleoprotein (RNP), Sm, and ...

Anti-Ro (SS-A) is an autoantibody associated with SLE or Sjögren’s syndrome. What is Sjögren’s syndrome? - Sjögren’s syndrome is an autoimmune disorder in which the body's immune system mistakenly reacts to the tissue in glands that produce moisture, such as tear and salivary glands.

SS-A (Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B (La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. SS-A cannot be demonstrated by immunofluorescence (it is soluble in the buffers used), but SS-B may be seen as a speckled antinuclear pattern.

Anti-Ro (SS-A) antibodies occur in 40-50% of SLE, 60-75% of primary Sjogren's syndrome (PSS) and in a high proportion of secondary SS whether the associated disease is in SLE, RA, PSS, polydermato-myositis, or primary biliary cirrhosis, but is >90% of subacute cutaneous lupus and in vasculitis-associated SS.

A positive result for SSA (Ro) or SSB (La) antibodies is highly suggestive of a diagnosis of Sjogren syndrome. The presence of isolated anti-SS-B/La antibody has low positive predictive value of Sjogren syndrome.

Anti-SSA 52 are linked with antibodies to tRNA synthetases like Jo-1, PL-7, PL-12, EJ and OJ, which are often found in patients with interstitial lung involvement.

Elevated Anti-Ro (SS-A) antibody levels are primarily associated with autoimmune diseases, notably Sjögren's syndrome and Systemic Lupus Erythematosus (SLE). They play a crucial role in the diagnosis of these conditions, given their strong correlation.