Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene. [5][6] LEKTI is a large multidomain serine protease inhibitor expressed in stratified epithelial tissue.

Mar 30, 2025 · Complete information for SPINK5 gene (Protein Coding), Serine Peptidase Inhibitor Kazal Type 5, including: function, proteins, disorders, pathways, orthologs, and expression.

The SPINK5 gene provides instructions for making a protein called LEKT1. LEKT1 is a type of serine peptidase inhibitor. Serine peptidase inhibitors control the activity of enzymes called …

Feb 5, 2024 · Here we describe a novel and viable, Spink5 conditional knock-out (cKO) mouse model, allowing to study NS progression. By combining transcriptomics and proteomics, we determine a disease...

Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions. Objective: To determine whether genetic …

Feb 8, 2025 · Our study shows that SPINK5 can inhibit the proliferation, migration, and invasion of esophageal cancer cells by inhibiting Wnt/beta-catenin signaling pathway, and thus plays an important role in the development of esophageal cancer, and may serve as a treatment target of esophageal cancer.

At least 70 SPINK5 gene mutations have been identified in people with Netherton syndrome, a disorder involving skin and hair abnormalities and a high risk of allergies, asthma, and an inflammatory skin condition called eczema. Mutations in the SPINK5 gene result in a LEKT1 protein that is unable to control serine peptidase activity.

The SPINK5 gene, which resides on 5q31-q32, encodes a 15-domain serine protease inhibitor, LEKTI, that is expressed in epithelial and mucosal surfaces and in the thymus.

Jan 4, 2025 · Clinical resource with information about SPINK5, Netherton syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Chromosomal location: 5q32 OMIM: 605010 HGNC: 15464 UniProtKB: Q9NQ38 Genatlas: SPINK5