Aug 21, 2008 · We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to achieve the benefits of...

The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes for a membrane-bound sodium-independent organic anion transporter protein (OATP1B1) that is involved in active cellular influx of many endogenous and xenobiotic compounds.

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein …

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. [5] [6] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. [7]

SLCO1B1 encodes for one of the major hepatic influx transport proteins organic anion transporting polypeptide 1B1 (OATP1B1), also referred to as SLCO1B1, and previously as OATP-C, OATP2, and liver specific transporter 1 (LST-1).

Mar 30, 2025 · SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include Hyperbilirubinemia, Rotor Type and Gilbert Syndrome. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Tezacaftor Pathway, Pharmacokinetics.

Sep 17, 2018 · Performing SLCO1B1 testing led to an increased willingness by providers to reinitiate statins and improved patient perceptions of statin therapy. This translated into a 20 mg/dL reduction in LDL-C levels during the trial in the GIST group and a 14.9 mg/dL reduction in the usual care group that received the pharmacogenetic test results at the ...

The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter.

SLCO1B1 is a drug transporter that helps the body break down and get rid of certain medicines after they are no longer needed. A pharmacogenomic test can help your medical team know well your SLCO1B1 transporter will work.