Oct 10, 2017 · We found that SHP-deficient mice hearts hypertrophied without functional change and exhibited less ectopic lipid accumulation after a high fat diet (HFD), likely resulting from a reduction in lipogenesis regulated by PPARγ.

Here we show that global Fxr −/− Shp−/− double knockout (DKO) mice are refractory to weight gain, glucose intolerance and hepatic steatosis when challenged with high-fat diet. DKO mice display an inherently increased capacity to burn fat and suppress de novo hepatic lipid synthesis.

Oct 10, 2017 · The small heterodimer partner (SHP) regulates fatty acid oxidation and lipogenesis in the liver by regulating peroxisome proliferator-activated receptor (PPAR) γ expression. SHP is also abundantly expressed in the myocardium.

Feb 7, 2018 · Here, we show that Pemt and Gnmt, key one-carbon cycle genes regulating PC/SAM levels, are downregulated after feeding, leading to decreased PC and increased SAM levels, but these effects are...

BA down-regulate hepatic lipogenesis by activating the FXR-small heterodimer partner (SHP) pathway. We tested the role of SHP in fatty liver disease (NAFLD) improvement after VSG. Wild type (WT), SHP liver-transgenic (SHP-Tg) and SHP knockout (SHP-KO) high-fat diet (HFD) fed mice underwent either VSG or Sham surgery.

May 1, 2017 · Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac metabolism and inflammation. Mice fed a high-fat diet (HFD) displayed glucose intolerance accompanied by increased cardiac mRNA levels of Shp.

Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac metabolism and inflammation.

Jul 3, 2020 · To investigate the role of hepatocyte SHP-1 on the development of NASH, hepatocyte-specific SHP-1 knockout mice (Ptpn6 HKO) and their normal littermates (Ptpn6 f/f) were fed with MCD diet for 4 weeks. The results showed that 4-week MCD diet resulted in substantial body weight loss in both group.

Aug 5, 2023 · In this investigation, we found that HFD-induced rats and FFAs-induced HepG2 cells had low expression of FXR and SHP and high expression of SREBP1C, ACC1, and FASN. These findings imply that the FXR signaling pathway …

Feb 2, 2010 · In the present study, we generated fat-specific SHP-overexpressed transgenic (TG) mice and determined the potential role of SHP activation, specifically in adipocytes, in the regulation of adipose tissue function in response to stressors.