Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) [2] is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. [3] .

The genome of SARS-CoV-2 is comprised of a single-stranded positive-sense RNA . The newly sequenced genome of the SARS-CoV-2 was submitted in the NCBI genome database ( NC_045512.2 ) ~29.9 Kb in size [ 11 ].

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as “the novel coronavirus” due to genome variation relative to previously identified coronaviruses, is a positive sense RNA virus and the etiological agent of COVID-19.

Jun 24, 2021 · SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown.

Here, I review the current understanding of the molecular biology of coronaviruses and their host interactions, bringing together knowledge of the infection process to aid in the development of therapeutic drugs and/or vaccines against SARS-CoV-2.

Jul 1, 2021 · SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the SARS-CoV-2 RNA interactome, we here develop a robust ribonucleoprotein (RNP) capture protocol and identify 109 host factors that di …

Sep 28, 2021 · Here we develop a simplified SPLASH assay and comprehensively map the in vivo RNA-RNA interactome of SARS-CoV-2 genome across viral life cycle.

Jul 19, 2021 · SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates.

Mar 31, 2025 · SARS-CoV-2 evolution balances many factors impacting its fitness including entry, immune evasion, packaging, RNA replication, and others. It has been difficult to independently investigate these effects due to the dominant phenotype of Spike on replication [ 6 ] and the laborious task of constructing multiple combinations of Spike recombinant ...

The SARS-CoV-2 pandemic has caused a global health crisis due to its high pathogenicity. The SARS-Unique Domain (SUD) in the non-structural protein Nsp3 of SARS-CoV-2 is hypothesized to play a critical role in viral replication and pathogenesis by interacting with host RNA G-quadruplex (G4) structures, but the molecular mechanisms remain unclear.