The downstream Akt protein acts against autophagy initiation in response to increases in ROS levels under nutrient-rich conditions. Akt acts by activating a mechanistic target of the rapamycin complex 1 (mTORC1) and by arresting autophagic gene expression.

Oct 24, 2019 · Moreover, chaetocin was shown to inactivate the PI3K/AKT pathway by inducing ROS generation; AKT-1 overexpression also attenuated chaetocin-induced apoptosis. Taken together, these results reveal...

Here, we report a novel mechanism by which ROS facilitated cell death through activation of AKT. We initially observed that ROS increased expression of phosphorylated AKT (p-AKT) in 22Rv1 human prostate cancer cells.

Jul 24, 2018 · In this study, we provide evidences that mtROS induce PTEN oxidation to stimulate PI3K/AKT/mTOR signaling pathway and thus promote autophagy, which is required for muscle differentiation and...

Nov 17, 2020 · Akt activation up-regulates the intracellular levels of reactive oxygen species (ROS) by inhibiting ROS scavenging. Of the Akt isoforms, Akt3 has also been shown to up-regulate ROS by promoting mitochondrial biogenesis.

Dec 15, 2010 · These mutant HPs contain increased ROS, overactive intracellular signalling through the AKT/mammalian target of rapamycin signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling.

Combination treatment of Rhein and oxaliplatin synergistically enhanced apoptosis of PC cells through increased generation of intracellular reactive oxygen species (ROS) and inactivation of the PI3K/AKT pathway.

May 15, 2018 · PI3K/Akt signaling facilitates ROS detoxification and redox homeostasis. The concomitant increase in the cellular antioxidant response is necessary for redox homeostasis, and this is largely mediated through NRF2 signaling, glutathione metabolism, and production of …

Nov 2, 2020 · Akt activation up-regulates the intracellular levels of reactive oxygen species (ROS) by inhibiting ROS scavenging. Of the Akt isoforms, Akt3 has also been shown to up-regulate ROS by promoting mitochondrial biogenesis.

Jan 8, 2022 · Here, we show that the metabolic reprogramming that facilitates 5-FU resistance in CRC arises from HIF-1α upregulation in non-classical ways, by ROS and the Wnt/β-catenin signaling pathway, independently from external oxygen concentrations.