Rev (HIV) - Wikipedia
Rev is a transactivating protein that is essential to the regulation of HIV-1 (and other lentiviral) protein expression. A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs.
The HIV-1 Rev response element - PubMed Central (PMC)
The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates.
HIV Rev response element - Wikipedia
The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs.
The HIV-1 Rev protein - PubMed
The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal.
Rev Protein - an overview | ScienceDirect Topics
The HIV Rev protein determines how well HIV-infected cells are recognized by CTLs by regulating the expression of viral late genes, an important source of antigenic peptide.
HIV Rev Assembly on the Rev Response Element (RRE): A …
HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. After translation, Rev enters the nucleus and binds the Rev response element (RRE), a ~350 nucleotide, highly structured element embedded in the env gene ...
Rev (HIV) - an overview | ScienceDirect Topics
Aug 1, 2010 · In HIV-1, a “regulator of expression of virion proteins” referred to as the Rev protein defeats cellular limitations on the transport of unspliced and incompletely spliced mRNA out of the nucleus.
The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev …
HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA motif, the Rev-response element (RRE), forming a complex that engages with the host nuclear export machinery.
rev Rev [Human immunodeficiency virus 1] - Gene - NCBI
Dec 3, 2024 · Title: CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev. CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
155908 - Gene Resultrev Rev [] - National Center for …
Dec 3, 2024 · Results suggest that rev protein, HIV-1 (Rev) regulates the association of nuclear cap-binding protein NCBP 80 kDa subunit (CBP80) and eukaryotic translation initiation factor 4A1 (eIF4AI) with the unspliced mRNA in the cytoplasm and the nucleus, respectively, during HIV-1 …