Ran's intrinsic GTPase -activity is activated through interaction with Ran GTPase activating protein (RanGAP), facilitated by complex formation with Ran-binding protein (RanBP). GTPase-activation leads to the conversion of RanGTP to RanGDP, thus closing the Ran cycle.

In the nucleus, Ran-GTP (filled diamonds, purple) binds to importin β and dissociates the transport complex. Ran-GTP and importin β shuttle back to the cytosol, where Ran-GTP is hydrolyzed by cytosolic RanGAP1 and RanBP1 to Ran-GDP (open diamonds, white).

Nov 30, 2023 · The Ran (Ran-related or Ras-like nuclear) protein is the single member of the Ran subfamily, and the most abundant small GTPase in the cell. Like the other small GTPases, Ran functions as a molecular switch, converting between the active GTP-bound and inactive GDP-bound conformations.

Several elegant studies indicate that the small GTPase called Ras-related nuclear protein (Ran) is a central regulator of several cell cycle events. In the 1990s, scientists first...

Mar 30, 2025 · RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of …

May 26, 2020 · Ran regulates nucleo-cytoplasmic transport of molecules through the nuclear pore complex and controls cell cycle progression through the regulation of microtubule polymerization and mitotic spindle formation.

Ran GTPase has multiple functions during the cell division cycle, including nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. The activity of Ran is determined by both its guanine nucleotide-bound state and its subcellular localization.

Jul 23, 2002 · Ran–GTP near chromosomes destabilizes the inhibitory complexes, and allows localized spindle assembly factor activity. Far from chromosomes, Ran–GTP undergoes nucleotide hydrolysis, recycling importin β and allowing it to …

Mar 26, 2025 · RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of …

Jul 1, 2002 · The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope — that is, large...