Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 and …

Mar 26, 2025 · The RAD50 protein belongs to a dynamic complex with Mre11 and Nbs1 (nibrin) in order to facilitate DNA repair function near the site of damage (Qiu and Jun 2021; Bian et al., …

Here we introduce the DNA repair functions of Rad50-containing complexes and compare their architecture with the SMC complexes cohesin and condensin. ATP binding and hydrolysis are …

May 22, 2020 · We identified 103 mostly occurred mutations in the Rad50 protein domains and motifs, which only 42 mutations were classified as most deleterious. These mutations are …

We report here the crystal structure of the Thermotoga maritima Rad50 nucleotide-binding domain (tmRad50 NBD) in complex with the Rad50-interacting helix-loop-helix motif of Mre11 …

Human RAD50 deficiency is an autosomal recessive syndrome that has been reported in patients with microcephaly and short stature. Their clinical phenotype resembled Nijmegen Breakage …

Apr 7, 2025 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex …

Mar 3, 2007 · We propose a model for Rad50 that incorporates both ATPase and adenylate kinase reactions as critical activities that regulate Rad50 functions. The Mre11/Rad50 (M/R) …

Mar 21, 2017 · Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 …

Mar 30, 2025 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and …