Thermo Scientific Ribonuclease I (RNase I) is an endoribonuclease that preferentially hydrolyzes single-stranded RNA to nucleoside 3'-monophosphates via nucleoside 2', 3'-cyclic monophosphate intermediates. The enzyme does not require any metal ions for activity.

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene. [5][6] According to the US National Library of Medicine, "This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family.

RNase I degrades single-stranded RNA to nucleoside 3´ monophosphates via 2´,3´ cyclic monophosphate intermediates by cleaving between all dinucleotide pairs, 2,3 unlike RNase A, which cleaves only after cytosine and uridine.

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Processing by RNase 1 forms tRNA halves and distinct Y RNA fragments in the extracellular environment.

Mar 30, 2025 · RNASE1 (Ribonuclease A Family Member 1, Pancreatic) is a Protein Coding gene. Diseases associated with RNASE1 include Retinitis Pigmentosa 58 and Mesothelioma, Malignant. Among its related pathways are Budding and …

Ambion™ RNase I efficiently cleaves after all four bases of single-stranded RNA, in contrast to RNase A, which only cleaves after C and U residues. RNase I degrades all RNA dinucleotide bonds leaving a 5' hydroxyl and 2', 3' cyclic monophosphate. Supplied in …

Jan 4, 2025 · Data suggest that ribonuclease inhibitor (RNH1) protects HeLa cells from ribonuclease 1 (RNase 1). Title: Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases.

We discover that the human homolog of RNase 1 has a pH optimum for catalysis, ability to degrade double-stranded RNA, and affinity for cell-surface glycans that are distinctly higher than those of its homologs. These attributes have relevance for human health.

Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.

Jun 3, 2022 · Recent research on two particular family members, RNase 1 and angiogenin (RNase 5), has revealed numerous new functions for these enzymes in various biological niches, ranging from vascular homeostasis and inflammation to cellular growth and quiescence.