Feb 24, 2025 · Adult renal cell carcinoma (RCC) is a malignant epithelial neoplasm arising from renal tubular epithelium Essential features Sixteenth most common cause of death from cancer worldwide

May 2, 2024 · Clear cell renal cell carcinoma, WHO / ISUP grade 3, measuring 2.5 cm in greatest dimension (see comment) Tumor is confined within the renal capsule. All surgical margins are negative for carcinoma.

Feb 16, 2022 · Stains - Renal cell carcinoma (RCC); Anti renal cell carcinoma (RCC) antibodies detect a 200 kD glycoprotein (gp200), which is a surface membrane located on the brush border of proximal renal tubules

For cancer diagnosis, immunohistochemistry (IHC) results often serve as valuable diagnostic tools when staining is positive. However, when using IHC to subtype renal cell carcinoma (RCC), both positive and negative staining of key immunomarkers are comparatively important.

Mar 5, 2020 · A total of 214 renal tumors were analyzed using 10 possible IHC markers to differentiate subtypes, including three major renal cell carcinoma (RCC) subtypes, clear-cell type (50 cases), papillary type (50 cases), and chromophobe type (20 cases), and minor subtypes (MiT RCC, 13 cases; collecting duct carcinoma, 5 cases; and oncocytoma, 10 cases).

Jan 1, 2011 · Renal cell carcinoma (RCC) marker: A, Normal kidney—The staining is limited to the brush border of the proximal tubules. B, Oncocytoma—No staining. C, Clear cell RCC—Diffuse staining predominantly in the luminal side of the cell membrane, replicating the staining pattern of normal renal tubules.

Our marker panel is a clear advancement in terms of immunohistochemistry application for RCC subtype differentiation when papillary and clear cells are the predominant architecture as this is very crucial for further prognosis and targeted therapy because of the different behavior of each type. Conflict of interest

Immunohistochemical staining for CA IX, CK7, AMACR and TFE3 comprises a concise panel for distinguishing RCC with papillary and clear pattern.

In fumarate hydratase-deficient and succinate dehydrogenase-deficient RCC, highly specific IHC markers can strongly suggest the diagnosis. In the metastatic setting, PAX8 and carbonic anhydrase 9 are among the most helpful markers for confirming RCC and clear cell type, respectively; however, caution should be exercised in the absence of a ...

Apr 1, 2012 · Differential diagnosis may include clear cell renal cell carcinoma (RCC) with granular cells, chromophobe RCC or oncocytoma, and type-2 papillary RCC. B, Vimentin immunostaining showing strong and diffuse positive stain.