Our results suggest that phage infection stimulates Pycsar cyclases to produce cCMP and cUMP. To understand the roles of these molecules in mediating the bacterial response to infection, …

Nov 11, 2021 · We discovered a family of bacterial pyrimidine cyclase enzymes that specifically synthesize cCMP and cUMP following phage infection and demonstrate that these molecules …

3’,5’-cyclic uridine monophosphate (cUMP) and 3’,5’-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the phage defense system, named …

Apr 8, 2022 · Here we show that phages encode anti-CBASS (Acb) and anti-Pycsar (Apyc) proteins that counteract defence by specifically degrading cyclic nucleotide signals that …

The pyrimidine cyclase system for anti-phage resistance (Pycsar) uses cCMP or cUMP signaling molecules to activate a downstream effector that acts on the bacterial host and induces …

Defense systems encoding pyrimidine cyclases, denoted here Pycsar (pyrimidine cyclase system for antiphage resistance), are widespread in prokaryotes. Our results assign clear biological …

Nov 11, 2021 · The Pycsar cyclase enzyme senses the infection, which leads to production of second-messenger cCMP or cUMP. These second messengers activate effector proteins that …

Jul 4, 2024 · 3',5'-cyclic uridine monophosphate (cUMP) and 3',5'-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the phage defense system, …

Defense systems encoding pyrimidine cyclases, denoted here “Pycsar” for Pyrimidine Cyclase Systems for Antiphage Resistance, are widespread in prokaryotes. Our results assign clear …

Oct 1, 2023 · Recent research has placed the neglected non-canonical cNMPs cCMP and cUMP in the spotlight with respect to generators (Pyc), effectors (PycTIR and PycTM), and …