Stimulation of the RIG-I/MAVS Pathway by Polyinosinic ... - PubMed
Sep 15, 2015 · Polyinosinic-polycytidylic acid [poly (I:C)] is a known inducer of IFN-β but also costimulates an inflammatory response. The latter response is undesirable given the pre …
Poly(I:C) HMW | Synthetic dsRNA - InvivoGen
Polyinosinic-polycytidylic acid (i.e. poly (I:C)) is a synthetic analog of double-stranded RNA (dsRNA), a molecular pattern associated with viral infections. InvivoGen’s Poly (I:C) HMW …
Stimulation of the RIG-I/MAVS Pathway by …
Sep 15, 2015 · Polyinosinic-polycytidylic acid [poly (I:C)] is a known inducer of IFN-β but also costimulates an inflammatory response. The latter response is undesirable given the pre …
A synthetic double-stranded RNA, poly I:C, induces a rapid ... - PubMed
We hypothesized that viral dsRNA recognized by either TLR3 or RIG-I/MDA-5, affects the growth of human hematopoietic stem/progenitor cells. Here we show that polyinosinic polycytidylic …
Poly(I:C) (LMW) / LyoVec™ - InvivoGen
Poly (I:C) is a synthetic dsRNA polymer. Unlike naked poly (I:C) which is recognized by TLR3, transfected poly (I:C) is sensed by RIG-I/MDA-5 in a cell-type-specific manner [1,2]. Poly (I:C) …
Mechanisms of length-dependent recognition of viral double
Apr 18, 2023 · Retinoic acid-inducible gene I (RIG-I) is the most front-line cytoplasmic viral RNA sensor and induces antiviral immune responses. RIG-I recognizes short double-stranded …
| RIG-I activation invokes autophagy. (A) HEK293T cells were ...
In the present study, we... ... investigate whether the recognition of viral RNA by RIG- I can trigger autophagy, HEK293T cells were transfected with the RIG-I agonist, polyI:C, a synthetic...
Polyinosinic:polycytidylic acid - Wikipedia
Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly (I:C)) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. [1] Poly I:C is known to …
High-resolution HDX-MS reveals distinct mechanisms of RNA …
RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon …
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent ...
Sep 12, 2013 · Retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are paralogous receptors for viral double-stranded RNA (dsRNA) with …
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