Mar 30, 2025 · PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) is a Protein Coding gene. Diseases associated with PABPC1 include Rift Valley Fever and Dengue Virus . Among its related pathways are Peptide chain elongation and Nervous system development .

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. [5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability.

The PABPC1 gene, originally isolated and cloned in human melanoma cells by Grange et al. in 1978, is conserved throughout eukaryotes and is located on human chromosome 8 (31, 32). PABPC1 consists of four RNA binding domains (RRM1-4), a linker region and a …

Mar 18, 2025 · Our high-throughput CRISPR–Cas9 screening identified poly(A) binding protein cytoplasmic 1 (PABPC1) as a driver for CML progression in the BC stage.

Apr 7, 2025 · HIV-1 Rev interacting protein, poly (A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE. HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly (A)-dependent translation.

Jun 20, 2024 · In the H9 nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and trapped by the nuclear basket protein TPR to prevent their export. Modulating (A)-rich motifs in circRNAs alters their subcellular localization, and introducing (A)-rich circRNAs in H9 cytosols results in mRNA translation suppression.

Mar 5, 2024 · Clinical resource with information about PABPC1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

In this study, we report that hnRNPLL specifically associates with cytoplasmic PABPC1 (poly (A)-binding protein 1) in both T cells and plasma cells.

Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1 (PubMed:16356927). Directly interacts with IGF2BP1; the interaction is enhanced by SEPIN14P20 peptide RBPR (PubMed: 29476152 , PubMed: 32245947 ).

Jul 21, 2017 · In this study, we report that hnRNPLL specifically associates with cytoplasmic PABPC1 (poly(A)-binding protein 1) in both T cells and plasma cells. We found that although PABPC1 is not required for the alternative splicing of CD45, a primary target of hnRNPLL in lymphocytes, PABPC1 does promote the binding of hnRNPLL to the immunoglobulin mRNA ...