This review will focus on the plant PP2C family of protein phosphatases. Biochemical and molecular genetic studies in Arabidopsis have identified PP2C enzymes as key players in plant signal transduction processes.

Members of the PP2C class of protein phosphatases have emerged as key negative regulators of plant immunity, primarily from research in the model plant Arabidopsis thaliana, revealing the potential to employ PP2C proteins to enhance plant disease resistance.

The largest class of PPs is the phosphoprotein phosphatase (PPP) family comprising PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7, and the protein phosphatase Mg 2+ - or Mn 2+-dependent (PPM) family, composed primarily of PP2C.

In the nuclei of guard cells, the clade A type 2C protein phosphatases (PP2Cs) counteract SnRK2 kinases by physical interaction, and thereby inhibit activation of the transcription factors that mediate ABA-responsive gene expression. Under osmotic stress conditions, PP2Cs bind to soluble ABA receptors to capture ABA and release active SnRK2s.

Plant PP2Cs have been found as regulators of signal transduction pathways and also involved in development. PP2C functions emphasize the existence of sophisticated signaling pathways in plants, in which protein dephosphorylation plays a crucial role towards determining specificities.

In this article, we discussed the regulation by PP2C family members of the TNFα‐ASK1‐JNK and integrin‐ILK‐GSK3β‐β‐catenin signaling pathways, which participate in the stimulation of apoptosis and cell proliferation/survival, respectively.

Protein phosphatase 2C (PP2C) is a class of ubiquitous and evolutionarily conserved serine/threonine PP involved in stress responses in yeasts, mammals, and plants. Here, I present mutational analysis of two Arabidopsis thaliana PP2Cs, encoded by ...

Dec 19, 2024 · PP2Cs - is a divergent family of serine-threonine phosphatases involved in the regulation of various physiological and pathological conditions. PP2Cs can dephosphorylate the key players of cell...

Jun 22, 2012 · PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs.

Protein Phosphatase 2C, also known as PPM PP2C, is a family of enzymes in the human genome that require the presence of Mg2+ or Mn2+ for their activity. These enzymes are associated with cell growth, cellular stress signaling, and play a role in dephosphorylation processes in the central nervous system.