Oct 1, 2004 · Protein phosphatase 2A (PP2A) is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including those mediated by extracellular signal-regulated kinase (ERK) signaling.

Feb 2, 2006 · The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal‐regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is …

The CDK9‐Src‐PP2A network drove rapid and persistent phosphorylation of ERK and unleashed the production of complement C1r and C3, leading to complement activation and immunosuppression.

Protein phosphatase 2A (PP2A) is a family of mamma-lian serine/threonine phosphatases that is involved in the control of many cellular functions including those mediated by extracellular signal-regulated kinase (ERK) signaling.

Sep 15, 2020 · Key findings: PP2A activity was decreased both in calcified aortic valves and human VICs under osteogenic induction. The PP2A inhibitor LB100 aggravated the aortic valve calcification of mice. Furthermore, PPP2CA overexpression inhibited osteogenic differentiation of VICs, whereas PPP2CA knockdown promoted the process.

Oct 1, 2004 · Protein phosphatase 2A (PP2A) is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including those mediated by extracellular signal-regulated kinase (ERK) signaling.

Aug 7, 2009 · PP2A is known to regulate c-Raf-MEK-ERK signaling through both positive and negative mechanisms via a feedback loop [22,24]. Ras-GTP induces kinase suppressor of Ras (KSR) dephosphorylation of ser 392 by generating active PP2A, resulting in translocation of KSR to the cell membrane.

The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal-regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is unknown.

Jun 2, 2003 · The existence of a cholesterol-regulated HePTP/PP2A activity provides a molecular explanation for why ERK activity is sensitive to membrane cholesterol levels, and raises the possibility that ERK plays a role in regulating the traffic …

PP2A is an important negative regulator of the extracellular signal-regulated kinase (ERK) signaling pathway and is involved in the control of many cellular functions including metabolism, transcription, translation, RNA splicing, DNA replication, cell …