May 17, 2023 · Here we describe an anti-NINJ1 monoclonal antibody that specifically targets mouse NINJ1 and blocks oligomerization of NINJ1, preventing PMR. Electron microscopy studies showed that this antibody...

The authors discovered that, following cell death stimuli, the adhesion protein ninjurin-1 (NINJ1) accumulates at the cell surface and oligomerizes — a critical event for PMR (Figure 1B). This event occurs downstream of the gasdermin-mediated pore formation; therefore, NINJ1-mediated PMR is an additional regulatory step within cell death pathways.

Jan 20, 2021 · Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the...

May 16, 2013 · We have determined that PMR-1, the Caenorhabditis elegans ortholog of SPCA1, plays an essential role in embryogenesis. Pmr-1 strains isolated from genetic screens show terminal phenotypes, such as ventral and anterior enclosure failures, body morphogenesis defects, and an unattached pharynx, which are caused by earlier defects during gastrulation.

May 17, 2023 · During inflammasome-driven pyroptosis, NINJ1 induces plasma membrane rupture (PMR) downstream of the cell death executor gasdermin D (GSDMD), which in turn is activated by caspase-dependent...

To determine the role of nerve injury-induced protein 1 (NINJ1) introduced plasma membrane rupture (PMR) and damage-associated molecular patterns (DAMPs) release in the pathogenesis and progression of gout and to explore the potential of NINJ1 as a therapeutic target in gout.

NINJ1 mediates plasma membrane rupture (PMR) downstream of various cell death processes in mouse macrophages NINJ1 is a cell-surface protein with two transmembrane regions.

Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules termed damage-associated molecular patterns (DAMPs) that propagate the...

Feb 8, 2024 · Ninjurin-1 (NINJ1) is a recently identified active executioner of plasma membrane rupture (PMR), a process previously thought to be a passive osmotic lysis event in lytic cell death. NINJ2 is a close paralog of NINJ1 but it cannot mediate PMR.

Here, we investigate a potential ferroptosis role of ninjurin-1 (NINJ1), a recently identified executor of pyroptosis-associated PMR. We report that NINJ1 oligomerizes during ferroptosis, and that Ninj1-deficiency protects macrophages and fibroblasts from ferroptosis-associated PMR.