Nov 7, 2023 · Under hypoxic circumstance, HIF-1 directly activates Pdk1 expression and suppresses metabolism through the tricarboxylic acid cycle (TCA) in the B lymphocyte cell line . Therefore, we are ...

Mar 1, 2022 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1 low AMLs are OXPHOS-driven, are...

PDK1, as an important direct target for metabolism, inhibits pyruvate flux to mitochondrial respiration. A rescue of PDK1 expression in Wnt-inhibited cancer cells rescues glycolysis as well as vessel growth in the tumor microenvironment [79,80].

PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Forced PDK1 expression in hypoxic HIF-1alpha null cells increases ATP levels, attenuates hypoxic ROS generation, and rescues …

Apr 19, 2021 · Pyruvate dehydrogenase kinases (PDK1–4) inhibit the TCA cycle by phosphorylating pyruvate dehydrogenase complex (PDC). Here, we show that PDK family is dispensable for murine embryonic development and that BCKDK serves as a compensatory mechanism by inactivating PDC.

Dec 13, 2005 · PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Forced PDK1 expression in hypoxic HIF-1α null cells increases ATP levels, attenuates hypoxic ROS generation, and …

Apr 19, 2021 · Pyruvate dehydrogenase kinases (PDK1-4) inhibit the TCA cycle by phosphorylating pyruvate dehydrogenase complex (PDC). Here, we show that PDK family is dispensable for murine embryonic development and that BCKDK serves as a compensatory mechanism by inactivating PDC.

Here, we demonstrate that downregulation of pyruvate dehydrogenase kinase 1 (PDK1), an enzyme of glycolytic cascade, enhances maximal respiration of cancer cells by upregulating mitochondrial complexes of oxidative phosphorylation (OXPHOS) and improves tumor response to tyrosine kinase inhibitors by promoting apoptosis.

PDK1, a downstream target of hypoxia inducible factor 1 alpha (HIF1α), is upregulated in a number of cancers including ovarian cancer (OCa) , gastric cancer (GCa) (37, 38), colorectal cancer (CRCa) , PCa , and acute myeloid leukemia (AML) .

Pyruvate dehydrogenase kinase 1 (PDK1) is a key regulatory enzyme in glucose metabolism, inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA.