Feb 11, 2025 · Inhibition of LZK suppressed tumor growth in MAP3K13 -amplified xenografts derived from HNSCC patients. LZK stabilized the transcription factor c-MYC through its kinase activity and gain-of-function mutants of p53 in a kinase-independent manner.

Nov 29, 2023 · TP53 regulates MYC, and MDM2/XPO1 inhibition disrupted the c-MYC–regulated transcriptome, resulting in the synergistic induction of apoptosis in acute myeloid leukemia (AML). Unexpectedly, venetoclax-resistant AMLs express high levels of c-MYC and are vulnerable to MDM2/XPO1 inhibition in vivo.

Oct 5, 2020 · Although p53 repression in cancer cells is frequently associated with the loss of ARF, we disclose here an alternate mechanism whereby c-Myc inactivates p53 through the actions of the...

Feb 28, 2014 · In this study, we show that c-Myc is essential for the induction of apoptosis within the intestinal crypt due to the inability of c-Myc-deficient cells to efficiently upregulate p53.

The principal model for the p53-independent mechanism of apoptosis is that the tumor suppressor p14, which binds to MYC directly and blocks the transcription of MYC canonical target genes, also inhibits MYC-induced hyperproliferation and transformation (16,17).

It has been shown that c-Myc negatively regulates the promoter of BRD7, a transcriptional cofactor of p53 . p53 downregulates M2 macrophage polarization through the p53/MDM2/c-Myc axis . p21 may be one of the targets of p53 regulation of M2-type macrophages. p21, as a downstream of p53, is upregulated during M2-type macrophage polarization.

Feb 11, 2025 · Many cancers of the head and neck, referred to as HNSCCs, are driven by the undruggable transcription factors c-MYC or mutant p53. Funk et al. found that these oncogenes can be disrupted in HNSCCs by targeting the kinase LZK, another commonly overexpressed protein encoded by MAP3K13.

Sep 21, 2017 · We investigated how cells redistribute global transcriptional activity in response to DNA damage. We show that an oscillatory increase of p53 levels in response to double-strand breaks drives a counter-oscillatory decrease of MYC levels.

Oct 5, 2020 · MILIP functions to promote p53 polyubiquitination and turnover by reducing p53 SUMOylation through suppressing tripartite-motif family-like 2 (TRIML2). MILIP upregulation is observed amongst diverse cancer types and is shown …

Dec 17, 2017 · Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1.