For example, p27 Kip1 binds to cyclin D either alone, or when complexed to its catalytic subunit CDK4. In doing so p27 Kip1 inhibits the catalytic activity of Cdk4, which means that it prevents Cdk4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein.

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The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

P27 may refer to: CDKN1B, cyclin-dependent kinase inhibitor 1B ČZ vz. 27, a pistol IFI27, interferon alpha-inducible protein 27 Papyrus 27, a biblical manuscript Phosphorus-27, an isotope of phosphorus Pixley Airport, in Tulare County, California, United States Projekt-27, an intelligence-gathering unit of the Swiss Armed Forces

Sep 1, 2020 · This review focuses on noncanonical, CDK-independent functions of p27 in migration, invasion, development, and gene expression, with emphasis on how transcriptional regulation by p27 illuminates its actions in cancer.

p21 or p27 protein is able to interact with cyclin-CDK complexes within the nucleus and hence regulate the cell cycle. p21 and p27 are themselves regulated either by sequestration via cyclin-CDK complexes, or by phosphorylation on serine/threonine …

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming growth factor (TGF)-β.

Three features of p27 make it a strong candidate as a target to consider in cancer therapy. First, while not mutated or lost at the gene level, the abundance of the protein has proven to be a reliable prognostic marker for disease progression in a diverse group of human neoplasms.

Feb 8, 2025 · p27, also known as p27^Kip1, is a cyclin-dependent kinase inhibitor that regulates the cell cycle by binding to and inhibiting cyclin-CDK complexes, particularly during the G1 to …

In this review, we focus on the multiple function of p27 in cell cycle regulation, apoptosis, epigenetic modifications and post- translational modification, and briefly discuss the mechanisms and factors that have important roles in p27 functions.

Mutations, abnormal expression and mislocalization of p27 have been found in many diseases suggesting the important role of p27 in the pathogenesis of diseases.

The p27 protein is a global cyclin-dependent kinase inhibitor (encoded in chromosome 12p12–12p13.1) that can bind all essential cdk types to potentially intervene the cellular cycle in several phases, the earliest of which is the restriction point between early (growth factor dependent) G1 and later growth factor independent phases.

Sep 2, 2020 · Recent data indicate p27 regulates transcription and acts as a transcriptional coregulator of cJun. C-terminal p27 phosphorylation increases p27-cJun recruitment to and action on target genes to drive oncogenic pathways and repress differentiation programs.

Mar 14, 2004 · p27 controls cell proliferation by binding and regulating nuclear cyclin-dependent kinases (CDKs).

Dec 3, 2001 · The cyclin-dependent kinase (Cdk) inhibitor p27 Kip1 (p27) is an important regulator of the mammalian cell cycle (reviewed in Sherr and Roberts, 1995, 1999; Hengst and Reed, 1998). p27 negatively regulates G 1 progression by binding to cyclin–Cdk2 complexes and preventing their activity.

Jan 1, 2001 · P27 is the only cyclin-dependent kinase inhibitor known to date that has a unique role between cell cycle and mitotic stimuli. P27 functions as a major gatekeeper of the quiescent state in ...

p27, encoded by cyclin-dependent kinase inhibitor 1B (CDKN1B), is a key regulator of the cell cycle that inhibits CDK-cyclin complexes and cell cycle progression [5]. p27 plays a pivotal role in controlling cell cycle and cell proliferation, making it essential for maintaining cellular homeostasis.

Apr 18, 2025 · Candidate p27-targeting E3 ubiquitin ligases screening identified RNF7 as the direct downstream target for YTHDF1 in an m6A-dependent manner.

Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest.

The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin–proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas. p27 can be ...

p27 is a human gene on chromosome 6 and belongs to the cip/kip family. It encodes a cell cycle inhibitor protein that binds to cyclin D and CDK4 and causes arrest in G1 phase. p27 is activated by Transforming Growth Factor β (TGF β). [1]