3 days ago · Polyclonal Antibody for studying EIF2S1/eIF2-alpha (Ser52) phosphate. Validated for WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-eIF2α (Ser51) Antibody (CST #9721) is ready to ship.

Jun 8, 2020 · In synthesis, it appears that eIF2α phosphorylation is a central event for the stimulation of autophagy. The so-called integrated stress response 1, 2, 3 is characterized by the...

Eukaryotic Initiation Factor 2 (eIF2) is a eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA i Met to the ribosome in a GTP -dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma ...

This review addresses the role of translational control in adaptive responses to environmental stresses and the processes by which phosphorylation of the α subunit of eukaryotic initiation factor 2 (P-eIF2α) can modulate translation genome wide to restore protein homeostasis.

Jan 15, 2015 · Phosphorylation of the α subunit of the translation initiation factor eIF2 at serine 51 (eIF2 α P) is a master regulator of cell adaptation to various forms of stress with implications in...

Mar 9, 2017 · We found that pretreatment of cells with a natural disaccharide trehalose, a known autophagy enhancer, delays SG assembly and facilitates their premature post-stress disassembly. Mechanistically,...

Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of eIF2α on serine 51 results in a severe decline in de novo protein synthesis and is an important strategy in …

We discuss novel insight into the role and consequences of the phosphorylation of the translation initiation factor eIF2α in the context of stress responses and cell-cycle regulation. eIF2α is centrally located to regulate translation and its phosphorylation in response to different environmental challenges is one of the best characterized stres...

3 days ago · Phospho-eIF2alpha (Ser51) RmAb detects endogenous eIF2alpha only when phosphorylated at Ser51. The antibody does not recognize elF2alpha phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51. Human, Mouse, Rat, Monkey, D. melanogaster.

Mar 18, 2025 · Explore how eIF2alpha phosphorylation regulates protein synthesis, integrates stress signals, and influences cellular function in health and disease. Cells regulate protein synthesis to maintain homeostasis and adapt to environmental changes.