The Lockheed P-38 Lightning is an American single-seat, twin piston-engined fighter aircraft that was used during World War II. Developed for the United States Army Air Corps (USAAC) by the Lockheed Corporation, the P-38 incorporated a distinctive twin-boom design with a central nacelle containing the cockpit and armament.

Additionally, p38 regulates p53 activation either directly or indirectly through HBP1 . p53 acts as a tumor suppressor by controlling the G1/S checkpoint, and its activation results in the upregulation of p21Cip1/WAF1, GADD45, and 14-3-3σ proteins, hence inducing proliferation arrest [67,68].

This review focuses on activation of p38 in response to genotoxic stress induced DNA damage in p53 mutated or compromised state and its possible cross talk with telomere shelterin proteins. Thus p38 may act as an important target to treat various diseases and in majority of cancers in p53 mutated state.

Dec 1, 2018 · p38 MAPK signaling pathway in mutated or compromised function of p53. In cancer cells where p53 is mutated, p38 may perform the function of p53 either partially or fully and perform cell cycle arrest or apoptosis through molecular interplay between ATM and telomere shelterin complex.

Feb 22, 2025 · In this study, we demonstrated that USP38 directly binds to and deubiquitinates MDM2, thereby stabilizing MDM2 and downregulating p53 expression, which affects critical cellular processes such as...

Sep 30, 2015 · Activation of p38α has been proposed to mediate the antitumoral effects of some chemotherapeutic drugs. In colon cancer cell lines, p38α is necessary for the apoptosis induced by cisplatin and fluorouracil, which are accounted for by the p38α-mediated phosphorylation of …

In the beta human papillomavirus type 38 (HPV38) experimental model, the viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form in human keratinocytes (HKs), promoting cellular proliferation. Inactivation of p53 by different means strongly decreases the proliferation of HPV38 E6/E7 HKs.

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53mutations impact tumor progression.

May 2, 2013 · Phosphorylation of ERK, p38 MAPK, and JNK was observed in response to adenovirus-mediated over-expression of eIF5A1 or eIF5A1 K50A, along with phosphorylation and stabilization of the p53 tumor suppressor protein.