The Ordnungspolizei (Orpo, German: [ˈɔʁdnʊŋspoliˌtsaɪ], meaning "Order Police") were the uniformed police force in Nazi Germany from 1936 to 1945. [2] The Orpo was absorbed into the Nazi monopoly of power after regional police jurisdiction was removed in favour of the central Nazi government ("Reich-ification", Verreichlichung, of

Oropo is one of the main antagonists of the Krosmoz mythos. He is an Eliatrope that founded of Brotherhood, the Siblings, helping Lady Echo with the plan to gather all the demigods and children of the dragons, get the Six Eliatrope Dofus eggs, …

What is GRIN? The Germplasm Resources Information Network (GRIN) provides information about USDA national collections of animal, microbial, and plant genetic resources (germplasm) important for food and agricultural production.

Ordnungspolizei (Orpo) ranks were based on local police titles and were considered a separate system from the ranks of the SS. If a member of the Order Police was already an SS member or - upon application - became an SS member, he was automatically awarded an SS rank according to his police rank.

Ordnungspolizei ("Orpo") ranks were based on local police titles and were considered a separate system from the ranks of the SS. It was also possible for Orpo members to hold dual status in both the Orpo and the SS, meaning that two ranks could be held simultaneously.

Building on this foundation, we introduce a straightforward and innovative reference model-free monolithic odds ratio preference optimization algorithm, ORPO, eliminating the necessity for an additional preference alignment phase.

Mar 19, 2025 · Radiprodil targets N-methyl-D-aspartate receptor subtype 2B and has received FDA orphan drug designation for GRIN-related NDD. The phase 1b Honeycomb trial demonstrated radiprodil's tolerability and efficacy, with an …

Mar 12, 2024 · Building on this foundation, we introduce a straightforward and innovative reference model-free monolithic odds ratio preference optimization algorithm, ORPO, eliminating the necessity for an additional preference alignment phase.

Jan 7, 2025 · This post covers LLM preference alignment, focusing on key techniques like PPO, DPO, and ORPO. Understand how large language models (LLMs) can be aligned with human preferences. Learn about the latest advancements in LLM alignment and how these methods optimize models to follow specific rules and preferences.

Late last year, GRIN Therapeutics reported promising topline data from a Phase 1b/2a clinical trial (the Honeycomb Trial) evaluating radiprodil in GRIN-related neurodevelopmental disorder in patients with GoF variants, leading to the decision to advance to a Phase 3 trial.