There are several types of OI, and different classifications are used based on the severity of the disease or on the nature of the underlying gene defect. Type I is the mildest and most common form of OI.

Osteogenesis imperfecta (OI), also known as brittle bone disease, is an inherited disorder of the connective tissue. A child born with OI may have soft bones that fracture easily, bones that are not formed normally, and other problems.

Aug 18, 2024 · Type II is the most serious form of osteogenesis imperfecta. It causes severe complications, like underdeveloped lungs (due to poor rib cage development), serious bone deformities and multiple broken bones before birth.

As of September 2021, 19 different genes are known to cause the 21 documented genetically defined types of OI, many of which are extremely rare and have only been documented in a few individuals. [16][17] Diagnosis is often based on symptoms and may be confirmed by collagen biopsy or DNA sequencing. [10]

Feb 6, 2023 · Osteogenesis imperfecta (OI) is a genetic disorder of connective tissues caused by an abnormality in the synthesis or processing of type I collagen. It is also called brittle bone disease. It is characterized by an increased susceptibility to …

Dec 22, 2022 · There are eight major types of OI that can be classified as mild, moderate, or severe OI: Type I, which is the most common and mild form of OI that is dominantly inherited, is characterized...

What Are the Types and Symptoms of OI? The following are the most common symptoms for osteogenesis imperfecta. However, each individual may experience symptoms differently.

Nov 24, 2024 · Several forms of osteogenesis imperfecta (OI) have been classified, representing a wide variation in appearance and severity, and clinical features vary widely not only between types but within types.

Osteogenesis imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent cause. A classification system of different types of OI is commonly used to help describe how severely a person with OI is affected.

Broadly speaking, based on severity of the clinical picture, OI can be grouped into 4 classes – mild, moderate, severe, and extremely severe or lethal.